DISEASES

Disease-gene associations mined from literature

Literature associating G3BP1 and lung sarcoma

G3BP1 [ENSP00000377681]

Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity . Participates in the DNA- triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA . In addition, plays an essential role in stress granule formation . Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends . Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency . Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA . Phosphorylation-dependent sequence-specific endoribonuclease in vitro . Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR . ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210,

Synonyms:  G3BP1,  G3BP1p,  hG3BP1,  E5RH00,  E5RH42 ...

Linkouts:  STRING  Pharos  UniProt