DISEASES

Disease-gene associations mined from literature

Literature associating FOLR1 and malignant mesothelioma

FOLR1 [ENSP00000377284]

Folate receptor alpha; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114,

Synonyms:  FOLR1,  FOLR1p,  hFOLR1,  A0A024R5H1,  P15328 ...

Linkouts:  STRING  Pharos  UniProt