DISEASES

Disease-gene associations mined from literature

Literature associating EME1 and xeroderma pigmentosum group G

EME1 [ENSP00000376952]

Crossover junction endonuclease EME1; Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801,; Belongs to the EME1/MMS4 family.

Synonyms:  EME1,  EME1p,  hEME1,  D6RIT8,  F8W714 ...

Linkouts:  STRING  Pharos  UniProt  OMIM