DISEASES

Disease-gene associations mined from literature

Literature associating URI1 and neurodegeneration with brain iron accumulation 4

URI1 [ENSP00000376097]

Unconventional prefoldin RPB5 interactor 1; Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein; Belongs to the RNA polymerase II subunit 5-mediating protein family.

Synonyms:  URI1,  URI1p,  hURI1,  I3L0K5,  I3L104 ...

Linkouts:  STRING  Pharos  UniProt