Literature associating NLRP12 and type 1 diabetes mellitus 8
NLRP12 [ENSP00000375653]
NACHT, LRR and PYD domains-containing protein 12; Plays an essential role as an potent mitigator of inflammation . Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways . Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway . In turn, promotes bacterial tolerance . Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation . Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity). ECO:0000269|PubMed:17947705, ECO:0000269|PubMed:30559449,
Synonyms: NLRP12, NLRP12p, hNLRP12, A0A0C4DFY3, A0A0C4DH17 ...