DISEASES

Disease-gene associations mined from literature

Literature associating RFC1 and progeria

RFC1 [ENSP00000371321]

Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.

Synonyms:  RFC1,  RFC1p,  hRFC1,  A0A1W2PP02,  D6RAD2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM