DISEASES

Disease-gene associations mined from literature

Literature associating E2F6 and ocular cancer

E2F6 [ENSP00000370936]

Transcription factor E2F6; Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'- TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase; Belongs to the E2F/DP family.

Synonyms:  E2F6,  E2F6p,  hE2F6,  A0A0S2Z3K8,  F8WC40 ...

Linkouts:  STRING  Pharos  UniProt  OMIM