DISEASES

Disease-gene associations mined from literature

Literature associating AKR1C4 and cytochrome P450 oxidoreductase deficiency

AKR1C4 [ENSP00000369814]

Aldo-keto reductase family 1 member C4; Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan- 3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha- hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route; Belongs to the aldo/keto reductase family.

Synonyms:  AKR1C4,  AKR1C4p,  hAKR1C4,  P17516,  P17516p ...

Linkouts:  STRING  Pharos  UniProt