Literature associating GDF9 and ovarian disease
GDF9 [ENSP00000367942]
Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. ECO:0000269|PubMed:20660033, ECO:0000269|PubMed:21632818,; Belongs to the TGF-beta family.
Synonyms: GDF9, GDF9p, hGDF9, B4DXG3, O60383 ...