DISEASES

Disease-gene associations mined from literature

Literature associating RECK and oral mucosa leukoplakia

RECK [ENSP00000367202]

Reversion-inducing cysteine-rich protein with Kazal motifs; Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) . Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 . ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex . Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity . Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) . ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314,

Synonyms:  RECK,  O95980,  O95980p,  hO95980,  8434 ...

Linkouts:  STRING  Pharos  UniProt  OMIM