DISEASES

Disease-gene associations mined from literature

Literature associating TCOF1 and nasal cavity lymphoma

TCOF1 [ENSP00000367028]

Treacle protein; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification . Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification .

Synonyms:  TCOF1,  TCOF1p,  hTCOF1,  A0A2R8Y4M7,  A0A2R8Y857 ...

Linkouts:  STRING  Pharos  UniProt