Literature associating NSUN6 and restrictive cardiomyopathy 1
NSUN6 [ENSP00000366519]
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) (PubMed:26160102, PubMed:27703015, PubMed:28531330). In vitro also methylates tRNA(Thr)(AGT) . Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates (PubMed:26160102, PubMed:27703015); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Synonyms: NSUN6, NSUN6p, hNSUN6, A0A0D9SF14, Q8TEA1 ...