DISEASES

Disease-gene associations mined from literature

Literature associating ZKSCAN3 and urinary tract papillary transitional cell benign neoplasm

ZKSCAN3 [ENSP00000366465]

Zinc finger protein with KRAB and SCAN domains 3; Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas. ECO:0000269|PubMed:21057542, ECO:0000269|PubMed:22531714,

Synonyms:  ZKSCAN3,  ZKSCAN3p,  hZKSCAN3,  Q9BRR0,  Q9BRR0p ...

Linkouts:  STRING  Pharos  UniProt