DISEASES

Disease-gene associations mined from literature

Literature associating CLYBL and dermatophytosis

CLYBL [ENSP00000365533]

Citramalyl-CoA lyase, mitochondrial; Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism . Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway . The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite . Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate . Also displays malyl-CoA thioesterase activity . Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro .

Synonyms:  CLYBL,  Q5JVB9,  Q5JVC0,  Q5JVC1,  Q5JVC2 ...

Linkouts:  STRING  Pharos  UniProt