DISEASES

Disease-gene associations mined from literature

Literature associating GGACT and Brooke-Spiegler syndrome

GGACT [ENSP00000365426]

Gamma-glutamylaminecyclotransferase; Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl- alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine; Belongs to the gamma-glutamylcyclotransferase family.

Synonyms:  GGACT,  M0R0M3,  M0R217,  Q9BVM4,  M0R0M3p ...

Linkouts:  STRING  Pharos  UniProt