DISEASES

Disease-gene associations mined from literature

Literature associating DXO and late-onset retinal degeneration

DXO [ENSP00000364498]

Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity); Belongs to the DXO/Dom3Z family.

Synonyms:  DXO,  A0A024RCW8,  DOM3Z,  F8WC68,  H7C5D2 ...

Linkouts:  STRING  Pharos  UniProt