DISEASES

Disease-gene associations mined from literature

Literature associating NOTCH4 and colon leiomyoma

NOTCH4 [ENSP00000364163]

Neurogenic locus notch homolog protein 4; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).

Synonyms:  NOTCH4,  NOTCH4p,  hNOTCH4,  A0A1U9X983,  Q99466 ...

Linkouts:  STRING  Pharos  UniProt  OMIM