Literature associating BMPR2 and scleroderma
BMPR2 [ENSP00000363708]
Bone morphogenetic protein receptor type-2; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Synonyms: BMPR2, BMPR2p, hBMPR2, A0A1W2PPB5, Q13873 ...