DISEASES

Disease-gene associations mined from literature

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Literature associating POLE3 and age related macular degeneration 2

POLE3 [ENSP00000363286]

DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex . Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 .

Synonyms:  POLE3,  POLE3p,  hPOLE3,  A0A024R829,  Q9NRF9 ...

Linkouts:  STRING  Pharos  UniProt

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.