DISEASES

Disease-gene associations mined from literature

Literature associating MBL2 and selective IgG deficiency disease

MBL2 [ENSP00000363079]

Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.

Synonyms:  MBL2p,  hMBL2,  P11226,  P11226p,  hP11226 ...

Linkouts:  STRING  Pharos  UniProt  OMIM