DISEASES

Disease-gene associations mined from literature

Literature associating UBE2D1 and color agnosia

UBE2D1 [ENSP00000363019]

Ubiquitin-conjugating enzyme E2 D1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . In vitro catalyzes 'Lys-48'-linked polyubiquitination . Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 . Ubiquitinates STUB1-associated HSP90AB1 in vitro . Lacks inherent specificity for any particular lysine residue of ubiquitin . Essential for viral activation of IRF3 . Mediates polyubiquitination of CYP3A4 . ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386,

Synonyms:  UBE2D1,  UBE2D1p,  hUBE2D1,  A0A024QZJ2,  A0A087WW00 ...

Linkouts:  STRING  Pharos  UniProt  OMIM