DISEASES

Disease-gene associations mined from literature

Literature associating UGT1A4 and Gilbert syndrome

UGT1A4 [ENSP00000362508]

UDP-glucuronosyltransferase 1-4; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity); Belongs to the UDP-glycosyltransferase family.

Synonyms:  UGT1A4,  UGT1A4p,  hUGT1A4,  P22310,  P22310p ...

Linkouts:  STRING  Pharos  UniProt  OMIM