DISEASES

Disease-gene associations mined from literature

Literature associating MACROH2A2 and plantar wart

MACROH2A2 [ENSP00000362352]

Core histone macro-H2A.2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Synonyms:  MACROH2A2,  A0A024QZP6,  H2AFY2,  Q5SQT3,  Q9P0M6 ...

Linkouts:  STRING  Pharos  UniProt