DISEASES

Disease-gene associations mined from literature

Literature associating EXO5 and intrahepatic cholestasis of pregnancy 1

EXO5 [ENSP00000361788]

Exonuclease V; Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'- directionality activity.

Synonyms:  EXO5,  EXO5p,  hEXO5,  Q9H790,  X6RCL8 ...

Linkouts:  STRING  Pharos  UniProt