DISEASES

Disease-gene associations mined from literature

Literature associating TSC22D3 and skin atrophy

TSC22D3 [ENSP00000361458]

TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).

Synonyms:  TSC22D3,  TSC22D3p,  hTSC22D3,  D6R8Z7,  D6R9J1 ...

Linkouts:  STRING  Pharos  UniProt