DISEASES

Disease-gene associations mined from literature

Literature associating AKR1A1 and liver cirrhosis

AKR1A1 [ENSP00000361140]

Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde . Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) . Displays no reductase activity towards retinoids (By similarity). ECO:0000250|UniProtKB:P51635, ECO:0000269|PubMed:10510318,

Synonyms:  AKR1A1,  AKR1A1p,  hAKR1A1,  HEL-S-165mP,  P14550 ...

Linkouts:  STRING  Pharos  UniProt