DISEASES

Disease-gene associations mined from literature

Literature associating PTPN1 and morbid obesity

PTPN1 [ENSP00000360683]

Tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c- src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 1 subfamily.

Synonyms:  PTPN1,  PTPN1p,  hPTPN1,  A8K3M3,  B4DSN5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM