Literature associating MAN1B1 and congenital disorder of glycosylation type IIo
MAN1B1 [ENSP00000360645]
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family.
Synonyms: MAN1B1, MAN1B1p, hMAN1B1, A0A087X064, H0YFU3 ...