DISEASES

Disease-gene associations mined from literature

Literature associating JUN and liposarcoma

JUN [ENSP00000360266]

Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation . Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells . Binds to the USP28 promoter in colorectal cancer (CRC) cells . ; Belongs to the bZIP family. Jun subfamily.

Synonyms:  JUN,  P05412,  P05412p,  hP05412,  1A02 ...

Linkouts:  STRING  Pharos  UniProt  OMIM