DISEASES

Disease-gene associations mined from literature

Literature associating POLL and uremic neuropathy

POLL [ENSP00000359181]

DNA polymerase lambda; DNA polymerase that functions in several pathways of DNA repair . Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA . Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity . ECO:0000269|PubMed:11457865, ECO:0000269|PubMed:12809503, ECO:0000269|PubMed:14627824, ECO:0000269|PubMed:15537631,; Belongs to the DNA polymerase type-X family.

Synonyms:  POLL,  Q5JQN9,  Q5JQP0,  Q5JQP1,  Q5JQP2 ...

Linkouts:  STRING  Pharos  UniProt