DISEASES

Disease-gene associations mined from literature

Literature associating TTK and hereditary mixed polyposis syndrome

TTK [ENSP00000358813]

Dual specificity protein kinase TTK; Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

Synonyms:  TTK,  D6REX1,  D6RF82,  D6RFY1,  D6RIC6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM