Literature associating SHOC2 and atrial heart septal defect
SHOC2 [ENSP00000358464]
Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Synonyms: SHOC2, SHOC2p, hSHOC2, Q9UQ13, X6RI37 ...