DISEASES

Disease-gene associations mined from literature

Literature associating RIT1 and Noonan syndrome

RIT1 [ENSP00000357305]

GTP-binding protein Rit1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation; Belongs to the small GTPase superfamily. Ras family.

Synonyms:  RIT1,  RIT1p,  hRIT1,  A0A494C0S1,  A0A494C0U3 ...

Linkouts:  STRING  Pharos  UniProt