DISEASES

Disease-gene associations mined from literature

Literature associating F11R and nemaline myopathy 4

F11R [ENSP00000357005]

Junctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 . The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T- cell and neutrophil transmigration . Involved in platelet activation . ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913, (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa; Belongs to the immunoglobulin superfamily.

Synonyms:  F11R,  F11Rp,  hF11R,  A0A087WY82,  Q6FIB4 ...

Linkouts:  STRING  Pharos  UniProt