Literature associating ADAMTS4 and osteogenesis imperfecta type 3
ADAMTS4 [ENSP00000356975]
A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Synonyms: ADAMTS4, ADAMTS4p, hADAMTS4, O75173, Q5VTW1 ...