DISEASES

Disease-gene associations mined from literature

Literature associating CCN2 and localized scleroderma

CCN2 [ENSP00000356954]

CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor- induced DNA synthesis; Belongs to the CCN family.

Synonyms:  CCN2,  CCN2p,  hCCN2,  P29279,  P29279p ...

Linkouts:  STRING  Pharos  UniProt  OMIM