DISEASES

Disease-gene associations mined from literature

Literature associating DDR2 and lung adenoid cystic carcinoma

DDR2 [ENSP00000356899]

Discoidin domain-containing receptor 2; Tyrosine kinase involved in the regulation of tissues remodeling . It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up- regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:30449416,; Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Synonyms:  DDR2,  DDR2p,  hDDR2,  A0A024R906,  Q16832 ...

Linkouts:  STRING  Pharos  UniProt