DISEASES

Disease-gene associations mined from literature

Literature associating POU2F1 and primary amebic meningoencephalitis

POU2F1 [ENSP00000356840]

POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

Synonyms:  POU2F1,  POU2F1p,  hPOU2F1,  A0A024R8Y2,  A0A0A0MSV5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM