DISEASES

Disease-gene associations mined from literature

Literature associating PAPPA2 and severe pre-eclampsia

PAPPA2 [ENSP00000356634]

Pappalysin-2; Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. ; Belongs to the peptidase M43B family.

Synonyms:  PAPPA2,  PAPPA2p,  hPAPPA2,  Q9BXP8,  Q9BXP8p ...

Linkouts:  STRING  Pharos  UniProt