Literature associating ADGRG6 and demyelinating polyneuropathy
ADGRG6 [ENSP00000356581]
Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins . Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons . Regulates neural, cardiac and ear development via G-protein- and/or N-terminus- dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity).
Synonyms: ADGRG6, ADGRG6p, hADGRG6, F5H054, F5H2L1 ...