DISEASES

Disease-gene associations mined from literature

Literature associating RO60 and scleroderma

RO60 [ENSP00000356416]

60 kDa SS-A/Ro ribonucleoprotein; RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation . Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes . ; Belongs to the Ro 60 kDa family.

Synonyms:  RO60,  RO60p,  hRO60,  A0A024R983,  D6RDN1 ...

Linkouts:  STRING  Pharos  UniProt