DISEASES

Disease-gene associations mined from literature

Literature associating ARMT1 and hereditary spherocytosis type 5

ARMT1 [ENSP00000356263]

Damage-control phosphatase ARMT1; Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1- phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues . Possibly methylates PCNA, suggesting it is involved in the DNA damage response .

Synonyms:  ARMT1,  ARMT1p,  hARMT1,  F2Z3I8,  F5GZY1 ...

Linkouts:  STRING  Pharos  UniProt