DISEASES

Disease-gene associations mined from literature

Literature associating PROX1 and lymphangiosarcoma

PROX1 [ENSP00000355925]

Prospero homeobox protein 1; Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3; Belongs to the Prospero homeodomain family.

Synonyms:  PROX1,  PROX1p,  hPROX1,  C9JU29,  Q92786 ...

Linkouts:  STRING  Pharos  UniProt