DISEASES

Disease-gene associations mined from literature

Literature associating PTPN14 and metatypical basal cell carcinoma

PTPN14 [ENSP00000355923]

Tyrosine-protein phosphatase non-receptor type 14; Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626,; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.

Synonyms:  PTPN14,  PTPN14p,  hPTPN14,  E2J9M0,  Q15678 ...

Linkouts:  STRING  Pharos  UniProt  OMIM