DISEASES

Disease-gene associations mined from literature

Literature associating TLR1 and parasitic protozoa infectious disease

TLR1 [ENSP00000354932]

Toll-like receptor 1; Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides . Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway . Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. ; Belongs to the Toll-like receptor family.

Synonyms:  TLR1,  TLR1p,  hTLR1,  D6RA99,  D6RAP2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM