DISEASES

Disease-gene associations mined from literature

Literature associating ETF1 and chronic purulent otitis media

ETF1 [ENSP00000353741]

Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA . Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes .

Synonyms:  ETF1,  ETF1p,  hETF1,  B7Z7P8,  D6RCB3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM