DISEASES

Disease-gene associations mined from literature

Literature associating SPINK5 and endocrine pancreas disease

SPINK5 [ENSP00000352936]

Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti- inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation- involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.

Synonyms:  SPINK5,  SPINK5p,  hSPINK5,  E5RFU9,  E5RG22 ...

Linkouts:  STRING  Pharos  UniProt  OMIM