DISEASES

Disease-gene associations mined from literature

Literature associating KLHL9 and familial melanoma

KLHL9 [ENSP00000351933]

Kelch-like protein 9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Synonyms:  KLHL9,  KLHL9p,  hKLHL9,  Q58EZ4,  Q9P2J3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM