DISEASES

Disease-gene associations mined from literature

Literature associating MARCHF5 and DOID:0111441

MARCHF5 [ENSP00000351813]

E3 ubiquitin-protein ligase MARCHF5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.

Synonyms:  MARCHF5,  MARCHF5p,  hMARCHF5,  MARCH5,  Q9NX47 ...

Linkouts:  STRING  Pharos  UniProt  OMIM