DISEASES

Disease-gene associations mined from literature

Literature associating TPM1 and dilated cardiomyopathy 1EE

TPM1 [ENSP00000351022]

Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells . Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction . Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Synonyms:  TPM1,  TPM1p,  hTPM1,  A0A024R5W6,  A0A087WTJ7 ...

Linkouts:  STRING  Pharos  UniProt